Minggu, 07 Oktober 2007

Blood Typing : Understanding antigen-antibody mechanism

What is your blood type? Most of our administrational purposes (such as passport, citizen identity) require this information, which would be important in certain emergency circumstances. This recognition of blood type involves the basic mechanism of antigen-antibody reaction.

Main principle: the antigen contained by red blood cells (RBCs) will react with particular antibody in the foreign substances

This observation will remind us to the process. Sample blood in the test was obtained by injuring our finger tip using a sterile lancet needle. Before the treat, skin on the finger tip was wiped by alcohol wetted-cotton. Soon after blood came out, it is dropped to the four side of an object glass.

Four kinds of serum antibody (the blue anti-A, the yellow anti-B, the plain anti-AB and anti D which commonly known as “rhesus”) were applied by putting a drop of each in every side of blood. Mix the blood-antibody compound, and see the result. Parts showed grain-like appearance (agglutination) shows the type of the individual’s blood.

Sorry, the image I took has poor definition due to bad capturing technique.

As a result, the type of the blood we tested is B. It showed agglutination in mixing with anti-B (yellow) and anti-AB (plain) antibody. It means that the blood (in its RBCs) contains antigen B. What about the anti-D (Rhesus) test? It shows no agglutination that the sample was stated to be Rhesus-negative.

This phenomenon is a simple example in understanding antigen-antibody mechanism, as the study could be largely broadened in the field of immunology.

2 komentar:

Yuki Tobing mengatakan...

I know most of the things written in this article since I learned them all before, hehe, but I do still have a question concerning blood typing..

have you ever seen books sold in Gramedia entitled "Diet Berdasarkan Golongan Darah", what do you think? I have checked what people with A blood type like me can eat and can not eat. Sadly, the author suggested us not to eat red meat, which means beef and pork.. We are even encouraged not to eat too much chicken.. ccckkk..

inda_ardani mengatakan...

thanks for your attention, dude

we know that hematology (science of all about blood) and immunology is such a large area, yet we can combine them with science of nutrition.

this article is recording my lab practical, we know that activities in undergraduate student is pretty simple

so, i'm afraid to tell u that i actually do not eligible answering your case since it should belong to dietrician either nutritionist :)

seems like you prefer meat to chicken ... well, in my humble opinion as the author 'suggest' which means it's not a compulsory thing, you can always eat meat anytime you wish though you must keep it in a limited amount :) we know every excessive thing is not good